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    Tamoxifen resistance in breast cancer elucidating mechanisms

    His contributions have uniquely reformulated the understanding of steroid hormone action in normal physiology and in hormone-dependent cancer.

    Breast cancer is not a single disease, but is instead a collection of diseases that have distinct histopathological features, genetic and genomic variability, and diverse prognostic outcomes.

    The expression of TBK1 was increased in subjects with breast cancer and was positively correlated with ERα, ERα Ser-305, and cyclin D1 expression.

    Subjects with tumors that highly expressed TBK1 had poor responsiveness to tamoxifen treatment.

    regulation by EGR1 and its coregulator NAB2 was investigated.

    We investigated the possible role of TANK-binding kinase 1 (TBK1) protein in tamoxifen resistance and found that phosphorylation by TBK1 at the Ser-305 site stabilized estrogen receptor α (ERα) and modulated its transcriptional activity.

    Ectopic expression of TBK1 rendered breast cancer cells resistant to tamoxifen.

    TBK1 inhibition sensitized breast cancer cells to tamoxifen-induced cell death.

    tamoxifen resistance in breast cancer elucidating mechanisms-7tamoxifen resistance in breast cancer elucidating mechanisms-2tamoxifen resistance in breast cancer elucidating mechanisms-22tamoxifen resistance in breast cancer elucidating mechanisms-83

    Accepting the NEJM cookie is necessary to use the website.

    The total amount awarded thus far is

    Accepting the NEJM cookie is necessary to use the website.

    The total amount awarded thus far is $1,790,649,040.

    Recipients of CPRIT awards include 98 academic institutions, non-profit organizations, and private companies all located in Texas.

    Thus, no individual model would be expected to completely recapitulate this complex disease.

    Here, the models commonly used to investigate breast cancer including cell lines, xenografts and genetically engineered mice, are discussed to help address the question: what is the most powerful way to investigate this heterogeneous disease?

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    Accepting the NEJM cookie is necessary to use the website.The total amount awarded thus far is $1,790,649,040.Recipients of CPRIT awards include 98 academic institutions, non-profit organizations, and private companies all located in Texas.Thus, no individual model would be expected to completely recapitulate this complex disease.Here, the models commonly used to investigate breast cancer including cell lines, xenografts and genetically engineered mice, are discussed to help address the question: what is the most powerful way to investigate this heterogeneous disease?

    ,790,649,040.

    Recipients of CPRIT awards include 98 academic institutions, non-profit organizations, and private companies all located in Texas.

    Thus, no individual model would be expected to completely recapitulate this complex disease.

    Here, the models commonly used to investigate breast cancer including cell lines, xenografts and genetically engineered mice, are discussed to help address the question: what is the most powerful way to investigate this heterogeneous disease?

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